The Genetics Recipe For Success
There is a recipe for success and a recipe for failure when it comes to health.
So many factors play a role in health but everything begins and ends with genetics. As you read this you have thousands of genes switching on and off. These genes are controlling which direction your health is moving. Continue to make poor choices and you're moving in the wrong direction.
Low Penetrance Genes (LPG) are genes that are modifiable using lifestyle, exercise and nutrition. The problem is that very few practitioners understand how to practically use genetic data.
There are 4 factors that are key to understanding LPG clinically:
- Understand single genes
- Understand how groups of genes interact
- Know what biomarkers to measure and track
- Initiate an effective plan
Take an ApoE4 gene, which is associated with Alzheimer’s Disease and CAD.
Depending on your geographic background the prevalence is 10-40% in a population.
This gene had great advantages in caveman days. When our immune systems had to be on the lookout for nasty microbes. In other words in the days when we ate what we killed, picked off a tree or dug from the ground and we needed our immune system to be a little more robust ... the ApoE4 gene was useful.
Nowadays, we live in a hyper-inflammatory environment caused by stress, pollution, poor sleep, toxins, nutrition, and extremism.
ApoE4 plays a role in transport and metabolism of fatty acids and people carrying this gene, at best, will have a 10% higher total cholesterol and LDL. ApoE4 carriers should thus reduce total fat intake to <10% and restrict saturated and trans fats, especially.
ApoE4 tends to be resistant to statins, unlike ApoE2. We know statins have a negative effect on ubiquinol which is vital in the mitochondria's role in ATP production. Ironically, an ApoE4 carrier that usually has a higher total cholesterol tends to be on statins.
Take an ApoE4 carrier patient presenting with any chronic pain. If this person has an increased waist circumference, high BP, on statins and attempting a ketogenic diet. This is a recipe for failure.
All these factors tend towards an increase in inflammation, oxidative stress and immune dysfunction.
Take this one step further (like the genetic result below), and add in poor detoxification genes (GSST, GSTM, COMT), inflammatory genes (IL6, TNFa), methylation genes (MTHFR), and mitochondria oxidative stress (MnSOD) and this is definitely a tough situation.
The irony is with all these LPG potentially going in the wrong direction ... it is still completely controllable.
A targeted personalized program and appropriate biomarker tracking is always a recipe for success.
How are you using genetics to achieve great patient outcomes? Have you done your own LPG genetic profile?